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The Outsourcing Facilities Association submitted a comment to the FDA estimating that compounding pharmacies filled roughly 80 million prescriptions for semaglutide in the last 12 months, The Washington Post reported

For many patients, these medications make following healthy habits and fighting food noise much easier

For women using GLP-1s for weight management, these sleep-induced cravings could undermine the appetite-suppressing effects of the medication

It plays a crucial role in glucose homeostasis by: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner [8] [9] Suppressing glucagon release , thereby reducing hepatic glucose production Slowing gastric emptying , which moderates postprandial glucose excursions Promoting satiety through actions on appetite centres in the brain GLP-1 receptor agonists mimic these physiological effects but with extended half-lives, allowing for once-weekly or once-daily administration

Monitoring protocols should address both the primary indication (diabetes or weight management) and potential hepatic effects, particularly in patients with known or suspected NAFLD