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This is fairly monumental and really is going to be paradigm-changing, Laique said of the Wegovy trial results, because at least in the pharmacotherapy space, you dont have a comparable drug yet. She was not involved with the clinical trial

Alternatives might include switching to a different GLP-1 medication (some patients tolerate one better than another despite similar mechanisms), reducing the maintenance dose to a level that produces fewer GI effects while still providing benefit, or transitioning to tirzepatide or another agent in the class

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Often, the loss of fat in the chest area may further emphasize gynecomastia, making such underlying granular tissue more visible