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Here are some key factors to weigh: First, think about convenience

This provides marginal benefit compared to semaglutide's seven-day half-life

Potential downsides Although current dual and triple agonists have not seen any long-term harmful effects so far, it is a possibility worth considering, given the history of anti-obesity drugs

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What Research Studies Have Compared These Two Medications Directly The primary direct comparison is SURMOUNT-5, a randomised controlled trial published in the New England Journal of Medicine (2025), which compared tirzepatide 10mg or 15mg against semaglutide 2.4mg in adults with obesity without diabetes over 72 weeks [10]