gip glp-1 dual agonist The action of tirzepatide on various organs. GLP-1: GLP-1 Receptor Agonists Explained for
Description
2025;26:e13841
10,11 Regarding IOP-lowering mechanisms, GLP-1RAs have been shown to inhibit sodium-potassium ATPase in the choroid plexus, decreasing cerebrospinal fluid secretion and lowering intracranial pressure
OWL833, an orally active nonpeptide GLP-1 receptor agonist, improves glucose tolerance by increasing insulin secretion and reduces food intake of cynomolgus monkeys
suggesting its detrimental effect on kidney health
As such, investments in oral GLP-1s may generate value well beyond a single indication, laying the groundwork for a new generation of orally delivered biologics
