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doi: 10.1016/j.jocn.2020.09.054 48 ZhouMChenSPengPGuZYuJZhaoGet al

These medicines have been shown to improve blood sugar control in people with diabetes and help with weight loss in people who are overweight or obese
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For example, empagliflozin treatment uniquely improved cardiovascular disease risk profiles, increased microbiota richness and SCFA-producing taxa, and shifted circulating metabolites toward a more favorable cardiometabolic profile compared to metformin in a randomized clinical trial of 76 treatment-nave adults with T2DM and at least one cardiovascular disease risk factor [38]
Somnolence has been reported in some patients (2 of 789 patients) taking RYALTRIS in controlled clinical studies in seasonal allergic rhinitis [see Adverse Reactions (6.1)]
