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Second, although not being able to penetrate into the brain, GLP1 receptor agonists elicit cFos immunoreactivity in many parts of the brain behind the BBB, demonstrating that their effects involve substantial downstream neuronal activation (Gabery et al., 2020

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[DOI] [PubMed] [Google Scholar] Shibasaki T, Takahashi H, Miki T, Sunaga Y, Matsumura K, Yamanaka M, Zhang C, Tamamoto A, Satoh T, Miyazaki J, et al