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GLP-1 receptor agonists got their start in an unlikely place: the mouth of a lizard

Weight gain during tirzepatide treatment can occur due to dose adjustments, metabolic adaptation, or individual peptide-pathway responses

The use of glucagon-like peptide-1 receptor agonists (GLP-1RAs), used to treat diabetes and obesity, may be associated with a wide range of health effects, both positive - such as a reduced risk of cardiometabolic disorders - and negative - an increased risk of gastrointestinal conditions or hypertension