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Adaptive thermogenesis is a reversible physiological response, not permanent metabolic damage

Proprotein convertase subtilisin/kexin type 9 inhibitors can also lower LDL-cholesterol levels and improve CV outcomes when added to statin therapy for secondary prevention

The increase in intracellular Ca 2+ from approximately 100 nmol/l to approximately 600 to 1000 nmol/l, triggered by glucose, glutamine and asparagine, is similar to that which triggers exocytosis in other secretory cells

Remarkably, NTS neurons are also the main source of locally produced GLP-1 in the brain

GLP-1 medications are FDA-approved for chronic weight management