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Figure 1 For example, after GLP-1RA stimulates the activation of AC (14), intracellular cAMP secretion increases, inhibits the signaling of the AKT and ERK1/2 pathways, and induces the apoptosis of tumor cells

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8,56,63 After binding with a ligand for a certain period, the receptor will trigger the inward sinking of the membrane, forming an endosomal compartment, which is called agonist-induced receptor internalization

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