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Any significant weight loss, whether through diet, bariatric surgery or pharmacotherapy, involves some lean mass reduction

Glucagon-like Peptide 1-Potentiated Insulin Secretion and Proliferation of Pancreatic -Cells

This kind of rigorous, data driven analysis is exactly what our field needs to move the conversation from "are NAMs ready?" to "are we benchmarking them fairly?" The bar for NAMs should be high and we are actively advocating for validation guidelines for specific NAMs models

The American Diabetes Association guidelines emphasize close monitoring and structured support whenever these medications are prescribed

Patients with heart failure with reduced ejection fraction (HFrEF) represent another group requiring individualized assessment