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Although not used in a single molecule, healthy human volunteers showed increased energy expenditure upon coinfusion of GLP-1 and Gcg, which was not apparent with GLP-1 infusion alone (Tan et al., 2013)

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van Bloemendaal L, IJzerman RG, Ten Kulve JS, et al

This shift mirrors historical inflection points in other scientific domains, where progress accelerated not through incremental refinement, but through redefinition of the underlying framework

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