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Apart from the -helical domain of G s and the extracellular domain (ECD) of GIPR, the presence of retatrutide, each individual receptor and heterotrimeric G s in the respective complexes were clearly visible in all three cryo-EM maps, thereby allowing unambiguous modeling of the secondary structure and side-chain orientation of all major components (Supplementary Fig

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Because GLP-1 therapies improve insulin regulation systemically, they may also enhance signaling pathways in the central nervous system

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