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Additionally, the expression of genes involved in GLP-1 biosynthesis was increased (proglucagon and prohormone convertase 3) 5

95% CI, 0.37-0.73

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These findings suggest that the weight lossalleviation of lipotoxicityimprovement of hyperandrogenism cascade exhibits strong consistency at the RCT level, although IR markers (e.g., HOMA-IR) do not necessarily improve synchronously (79)

The included studies varied in design, populations, drug regimens, treatment duration, and body-composition methods