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Data extraction and synthesis From the eligible studies, detailed variables were extracted to facilitate a structured narrative comparison

The thigh injection site offers psychological advantages for many patients: it is hidden under clothing, reducing self-consciousness, and remains accessible even for patients with limited hand dexterity or reduced flexibility

supplementation can support emotional well-being and immune function

The SUMO trials and FDA approval documentation established once-weekly dosing as the optimal schedule, with steady-state plasma levels achieved by day 7

Rinse with water or a fluoride mouthwash after vomiting or acidic drinks