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In May 2026, Phase 3 topline results from the TRIUMPH-1 trial across 2,339 participants showed an average 28.3 percent body weight reduction over 80 weeks at the highest dose, with 45.3 percent of those participants losing at least 30 percent of body weight a threshold previously achievable only through surgery

Jardiance can also help reduce the risk of heart-related death in adults with T2DM and known heart disease

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However, synaptic plasticity and memory formation are impaired in GLP-1 receptor knockout mice (118)
