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If semaglutide gives you adequate appetite control and steady weight loss with good tolerability, switching may not provide meaningful additional benefit

[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Lee PH, Stockton MD, Franks AS

Williams & Elmquist, 2012 )

Research suggests that visceral and ectopic fat (metabolically harmful fat) may be preferentially reduced during GLP-1 therapy, which represents a positive body composition change despite some lean tissue reduction

It should be highlighted that balanced partial agonists with globally reduced efficacy for coupling to both G proteins and arrestins should theoretically behave similarly, that is, formally confirmed biased agonism is not a requirement