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The model proposes that the interaction between the C-terminal domain of the ligand with the extracellular domain (ECD) of the receptor supports the engagement of the N-terminal domain of the ligand with the central transmembrane domain of the receptor, causing a conformational rearrangement that initiates the second messenger signaling (19, 21, 42)

[DOI] [PubMed] [Google Scholar] 31.Kopp K.O., Glotfelty E.J., Li Y., Greig N.H

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Consequently, it may not have been adequate for evaluating the long-term stabilization or improvement of retinal pathology following a sudden, drastic decrease in hemoglobin A1c levels