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Ayoub, M., Faris, C., Juranovic, T., Chela, H

Discoveries of GIP and GLP-1 The first incretin, GIP, was purified from canine intestinal extracts in the late 1960s (8) and initially named gastric inhibitory polypeptide (9) because the peptide inhibited gastrin-stimulated H + secretion (10)

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There are also some reports on the effect of GLP-1 on human type 2 pneumocytes, which showed GLP-1RA could increase the production of phosphatidylcholine through the protein kinase A (PKA) and protein kinase C (PKC) pathways and ultimately increase the secretion of surfactant in the lung tissue [81]