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Insulin and sulfonylureas require dose adjustment to prevent hypoglycemia

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10.1056/NEJMoa1411892 34

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Women face additional layers of complexity

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Higher effective doses: The dosing regimen allows for greater total GLP-1 receptor activation

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Boosting GIPR activity could directly affect the myocardium and indirectly influence cardiovascular function and outcomes through its systemic effects on other organs [13]

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