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Keywords: Glucagon-like peptide-1 receptor agonist, Cardiometabolic outcomes, Safety, Combination therapy, Health policy Search strategy and selection criteria

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Symptoms of overdose may include severe nausea, vomiting, and potentially hypoglycemia

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These studies are all Cardiovascular Outcomes Trials, which are large multi-country and multi-center RCTs

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GLP-1R agonists have been reported to have therapeutic efficacy on several MS animal models and in in vitro models [115,116,117,118]

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