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In this 52-week, 1,098-patient randomized trial, both the 0.75- and 1.5-mg doses of once-weekly dulaglutide proved superior to oral sitagliptin (Januvia) at the standard dose of 100 mg/day in key efficacy endpoints

Methods A MEDLINE search, limited to human clinical trials and using the search criteria GLP-1RA or DPP-4 inhibitor, identified seven head-to-head studies and one relevant post hoc analysis (all a GLP-1RA vs

Excess weight is associated with venous stasis, particularly in the lower limbs, and obesity is a well-established risk factor for venous thromboembolism

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