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Notable are the EMPA-REG OUTCOME trial, which showed a significant reduction in aminotransferases with empagliflozin 47 , and a meta-analysis of ten randomized controlled trials with 573 participants that confirmed the superiority of SGLT2 inhibitors over other antihyperglycemic agents in terms of improvement in hepatic and metabolic parameters 48

Terminology Table References: Boucher, J., Kleinridders, A., & Kahn, C

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The most common side effects are acid reflux, constipation, fatigue, headaches, indigestion, mild nausea, and vomiting, which Saleh says are often eliminated or lessened as the medication stays in the body and you shift your lifestyle and eating habits. To minimize these side effects, avoid foods that are spicy or high in fat, and eat smaller, more frequent meals