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Obesity at diagnosis is associated with inferior outcomes in hormone receptor-positive operable breast cancer
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KOL perspectives and clinical guidelines are increasingly emphasizing obesitys strong association with morbidity, mortality, and non-communicable diseases, thereby supporting greater adoption of medical therapies

Ndemethylation results in the formation of N-desmethyltamoxifen and is catalysed mainly via CYP3A4/5, and is followed by CYP2D6-mediated secondary metabolism to endoxifen ( Figure 1 )
