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SLIDESHOW See Slideshow Anal fissures An anal fissure is a fairly common, painful condition in which the lining of the anal canal is torn

Gastrointestinal symptoms like mild nausea, vomiting, or diarrhea can occur with either medication, and combining them may increase these effects during the first few weeks

It also helps reduce body weight by decreasing energy intake and increasing energy expenditure

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Many patients experience transient nausea 4-8 hours post-injection as their GLP-1 and GIP receptors adjust to the peptide signal