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The optimal ratio in receptor potency has yet to be found to optimize clinical benefits without imposing additional safety issues [29]

A series of (4-substituted prolyl) prolinenitriles as DPP-4 inhibitors were evaluated in a study by Kondo and coworkers (127)

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The other 30-40% may struggle with vomiting, diarrhea, and other digestive impacts, particularly when starting the medication or after increasing the dose

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