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In lean rats without T2DM, plasma levels of gluconeogenic amino acids were increased in a weight loss-independent manner after bariatric surgery, suggesting that substrate availability is not the limiting factor for reduced gluconeogenesis 29
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Tirzepatide is FDA-approved for adults with obesity (a BMI of 30 or more) or adults with overweight (BMI of 27 or more) who also have related health issues such as high blood pressure, obstructive sleep apnea, or type 2 diabetes
