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Description
This review examines the biological mechanisms underlying GLP-1 RA therapy in MASLD/MASH, analyzes the mechanistic distinctions between mono-, dual-, and triple agonists, and synthesizes current clinical evidence supporting their utilization in individuals with this condition.
Retatrutide titration schedule from the Phase 2 trial: 2mg starting dose escalating to 12mg every 4 weeks, plus a 6-week slow protocol for nausea-prone users
Further pharmacovigilance and mechanistic studies are warranted to clarify this potential association.
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