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Anti-Inflammatory Benefits of Semaglutide: State of the Art. Journal of Clinical & Translational Endocrinology , vol

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In fact, experimental data suggested that sDPP-4 acts as a pro-inflammatory adipokine (e.g., through the TLR pathway), while DPP-4 inhibition (with either vildagliptin, an enzymatic inhibitor, or mannose-6-phosphate, a competitive binding inhibitor) improves the inflammatory milieu [58]