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Gallbladder and biliary disease are common findings in patients with IBD 149 and given the known risks from GLP-1RA as described above, patient education regarding important symptoms to be aware of is crucial when initiating these treatments and caution is advised in patients with a history of biliary disease

It effectively reduces weight in diabetic and nondiabetic obese individuals [96]

McDonough, A

Semaglutide at a higher dose is being explored clinically for the treatment of non-diabetic obese patients, and an alternative oral formulation of semaglutide has completed Phase 3 clinical trials for type 2 diabetes

Lancet 376 (9739), 431439 (2010)