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US guidelines typically recommend reassessing response after approximately 3 months at a maintenance dose, with 5% weight loss considered clinically meaningful

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The antihypertensive effects of GLP-1 RAs are due to several mechanisms: natriuretic effects, vasodilation, and reduced sympathetic activity

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Ongoing drug development studies continue to evaluate long-term safety profiles through extended clinical trials, with current evidence suggesting favorable benefit-risk ratios for appropriately selected patients with metabolic disorders