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Almost 60 percent of adults have said they have heard at least some about these drugs, according to a 2024 KFF Health Tracking Poll

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Studies show semaglutide and tirzepatide can increase certain beneficial taxa while reducing diversity in ways that persist for weeks after dose adjustments

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Additionally, significant changes were noted in the composition of the bone matrix of these animals, with decreased enzymatic cross-linking of the collagenous matrix, which clearly worsened the compromised biomechanical strength and contributed to the observed bone fragility [44]