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Description
Research suggests this approach can help maintain more consistent appetite control

Trial data shows mild to moderate gastrointestinal issues such as nausea, vomiting, and diarrheacommon with GLP-1 medications

Methods Study design and participants SURMOUNT-1 was a phase 3 randomised, double-blind, placebo-controlled trial in which adults with a body mass index (BMI) 30 kg/m 2 or 27 kg/m 2 and at least one weight-related complication, excluding diabetes, were assigned to once weekly, subcutaneous tirzepatide (5 mg, 10 mg or 15 mg) or placebo for 72 weeks as an adjunct to lifestyle intervention

It is recommended to periodically check blood pressure and pulse during therapy

GLP-1RAs are associated with reduced hepatic insulin resistance, which contributes to enhanced glucose homeostasis and improved metabolic profiles in patients with metabolic disorder syndrome (Lin et al., 2024)
