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Crucially, several of these effects appear independent of weight loss, strengthening the argument that GLP-1s promote direct neurobiological benefits for brain health and dementia prevention

Diabetes Care 48 , 846859 (2025)

hence GLP1-R signaling can contribute to the regulation of sodium balance and maintain blood pressure in the normal range ( Further experiments are still required to elucidate the potential mechanisms by which GLP1-R activation increases Treg functions ( However, the effects of GLP1-RAs on immune regulation still remain uncertain