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PAR2 cleavage was quantified on Chinese hamster ovary (CHO)K1 cells stably transfected with human TF and endothelial protein C receptor (EPCR) and transiently transfected with FLAG-tagged PAR2-WT or PAR2-G37I mutants, as described previously (43)

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The data currently available derive from clinical trial populations, and real-world pharmacokinetics may differ

Because these medications slow digestion and can cause constipationa known trigger for diverticular flarespatients must prioritize hydration and bowel regularity to minimize risks
