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Suresh Ramalingam, executive director of Winship Cancer Institute of Emory University and the trials principal investigator, called the approval a major breakthrough for this patient group

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Its worth being clear-eyed about the studys limits: it was a single-center, retrospective chart review, not a randomized trial, and nearly a third of patients discontinued the medication, most often due to gastrointestinal side effects

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Melanie Jay, MD, MS, is a professor of medicine and population health at NYU Langone Health and a physician investigator specializing in obesity

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