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Its important to follow this guideline rather than jumping ahead to the maximum dose, since that can come with pretty severe side effects, Vash says, including nausea, vomiting, and severe abdominal pain

N Engl J Med 387 , 205216 (2022)

Acetylcholine acts on M3 muscarinic receptors expressed on endothelial cells, activating endothelial nitric oxide synthase (eNOS) and promoting NO production [20,21]

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Supportive care with cool compresses and over-the-counter antihistamines may provide relief if needed