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Boehringer Ingelheim / Zealand Pharma (ZLDPF): Survodutide (aka BI 456906) [44] [44] In a placebo-controlled study evaluating the GLP1R/GR dual agonist (Obesity Indication), patients received weekly subcutaneous injections of 4.8mg for a duration of 46 weeks

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Induced by exercise and cold exposure, METRNL promotes beige adipocyte formation and enhances glucose tolerance through immune-mediated mechanisms ( As with irisin, METRNLs receptor has not been definitively identified, limiting conventional drug development strategies

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A 2026 study published in Cardiovascular Diabetology found an association between GLP-1 use and lower risks of heart attack, stroke, heart failure and premature death among high-risk patients building on earlier evidence from Novo Nordisk's SELECT trial, which showed that Wegovy reduced major adverse cardiovascular events versus placebo in people with established heart disease