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Causes Genetic predisposition (notably among South Asians) Lifestyle factors: overeating, sedentary habits, high-calorie diets, urbanization Obesity and central adiposity leading to insulin resistance Progressive -cell dysfunction Existing Treatments and Their Effectiveness The management of diabetes primarily involves: Lifestyle Changes: Including diet modification and exercise

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Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis

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