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Retrieved February 8, 2024, from [6] Randomized, Controlled Trial of the FGF21 Analogue Pegozafermin in NASH [7] Akero Therapeutics Reports Statistically Significant Histological Improvements at Week 96 in Phase 2b HARMONY Study [8] Sagimet Biosciences Announces Positive Topline Results from Phase 2b FASCINATE-2 Clinical Trial of Denifanstat in Biopsy-Confirmed F2/F3 NASH [9] Merck to Present Data for Efinopegdutide (MK-6024), an Investigational GLP-1/Glucagon Receptor Co-agonist, in Patients with Nonalcoholic Fatty Liver Disease (NAFLD) at EASL 2023 [10] Already rolling in diabetes and obesity, Eli Lilly touts tirzepatide's midstage MASH win [11] Survodutide Phase II trial shows 83% of adults treated achieved groundbreaking results in liver disease due to MASH, with significant improvements in fibrosis

After intensive wash a substrate solution is added to the wells and color develops in proportion to the amount of GLP-1 bound in the initial step

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Clinicians should judiciously balance potential benefits against risks when considering the use of these agents in pregnant patients and, where feasible, engage in thorough preconception counseling.225,226 Future research should prioritize the evaluation of long-term safety outcomes during pregnancy and potential fetal effects to inform safer clinical practices