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Therefore, gene-environment interactions seem to be an important mediator for food preference, consumption and caloric intake

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However, the ELIXA (Evaluation of Lixisenatide in Acute Coronary Syndrome) trial found that the once-daily GLP-1 receptor agonist lixisenatide had a neutral effect on cardiovascular outcomes, neither increasing nor decreasing incidence relative to placebo (31)

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In addition to the shortage, the active ingredient itself also poses a problem

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