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If confirmed by a clinical trial, this could inform the clinical application of metformin such that, for example, drugs known to interact with OCT1 could be replaced with alternatives, allowing improved tolerance to metformin and enabling optimal metformin dosing

The responder rates were equally striking

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While their main role remains in diabetes treatment, certain GLP-1 therapies are also approved for weight management in individuals with obesity or overweight with comorbidities, given their modest but clinically meaningful effects on appetite regulation and body weight 2 , 6 , 7

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