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Andrews and colleagues (2009) demonstrated that MPTP-induced dopaminergic dysfunction is amplified in GHSR KO animals, and selective re-expression of GHSR1a in catecholaminergic neurons of GHSR KO animals reduced this degeneration
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Known adverse effects of exogenous HGH use (particularly at supraphysiological doses, as documented in authorised somatropin SmPCs) include: Acromegaly-like features coarsening of facial features, enlargement of hands and feet with prolonged use Fluid retention and peripheral oedema Carpal tunnel syndrome Joint and muscle pain (arthralgia and myalgia) Insulin resistance, glucose intolerance, and increased risk of type 2 diabetes Gynaecomastia (breast tissue development in men) Exacerbation of sleep apnoea Unmasking of hypothyroidism Benign intracranial hypertension presenting with severe or persistent headache, visual disturbances, nausea, or vomiting

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