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In a clinical trial of patients with type 2 diabetes, weekly tirzepatide at 5, 10, or 15 mg for 40 weeks resulted in an 8.512.4% weight loss, compared to 6.7% with semaglutide at 1 mg/week [29]

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In a phase 3 clinical trial, Zepbound led to an average weight loss of 22.5% body weight, or about 52 pounds, surpassing all currently available weight loss medications on the market

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From a management perspective, with the necessity of glucose-lowering medications like metformin or basal insulin in populations with T2DM complications, 61 combination products with routine injections or basal insulin may offer compliance advantages, simpler titration strategies (adjusting to maximum maintenance dose only once), and lighter economic burdens