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With the emergence of availability through compounding pharmacies and a rapid increase in PED use among the general population, there is an urgent need for high-quality, prospective data to inform about health risks

The following data were extracted for efficacy and safety assessment at the primary endpoint of each study: changes from baseline in glycated haemoglobin (HbA1c) and body weight and the incidence of nausea, vomiting or diarrhoea, hypoglycaemia, and patients discontinuing treatment because of adverse events

And while GLP-1 medications can cause lean mass loss alongside fat loss, estrogen supports muscle protein synthesis, which may shift the ratio toward better body composition

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