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This makes Retatrutide the first medication to achieve surgical level weight loss through pharmaceutical intervention alone

Both companies are betting there is a big untapped market of overweight people who would favor a pill instead

The UACR reductions were dose-dependent, larger at higher doses, and sustained through 72 weeks of treatment without any detrimental effect on estimated glomerular filtration rate

Pioglitazone did not reduce stroke compared with placebo, but it had a significant effect in preventing stroke recurrence in the PROspective pioglitAzone Clinical Trial In macroVascular Events (PROactive) [9]

Additionally, GLP-1 agonists may improve insulin sensitivity, which is closely linked to skin health