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GLP-1 receptor agonists, including semaglutide, have been associated with acute pancreatitis in postmarketing surveillance, though a definitive causal relationship has not been established

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[1] [2] Additionally, the immediate systemic exposure might provoke more severe gastrointestinal distress than typically experienced with subcutaneous administration

[DOI] [PubMed] [Google Scholar] 66.Compagnone NA, Bulfone A, Rubenstein JL, Mellon SH