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GLP1 agonists may risk muscle loss

Pharmacological therapies have demonstrated substantial effects in weight loss, appetite suppression and modulation of foodrelated thoughts

The general recommendation for a sample size to assess the safety of a weight-reduction drug is 3,000 subjects randomized to the investigational drug within the to-be258 recommended dosage range and no fewer than 1,500 subjects randomized to placebo for at least 1 year of treatment at the maintenance dosage Multiple #obesitytrials have successfully used flexible dosing regimens

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