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Evidence from experiments employing somatostatin receptor 2 (SSRT2) antagonists and SSRT2 knockout mice strongly suggests that GLP-1s inhibitory actions on -cells are indirect and partially mediated through somatostatin-dependent mechanisms (132)

PMID 33988478)

Physical activity helps maintain muscle tone throughout the body, including the muscles of the intestinal tract

use cautiously in patients with gout [16] [25] Myopathy risk : When combined with statins, increased risk of muscle symptoms requires monitoring Glucose effects : Dose-dependent increases in blood glucose and A1c Monitoring recommendations: Glucose monitoring is paramount, particularly during the first few weeks after initiating or adjusting either medication

These can assist patients in developing healthy lifestyle habits, such as a healthy diet, exercise, blood glucose monitoring and medication adherence