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Warnings and Precautions Anaphylaxis and Serious Hypersensitivity Reactions: In clinical trials of lixisenatide, there have been cases of anaphylaxis and other serious hypersensitivity reactions including angioedema
37 Indeed, GLP-1R is present beyond the confines of the pancreas and extends to a multitude of organs and tissues throughout the body
Where systems are restrictive, clinicians adapt by reserving therapy for specific situations, even when they believe it could be beneficial
Overall, between 5% and 10% of subjects stopped treatment in GLP-1 receptor agonist trials because of side effects (17)
GLP-1RAs may not effectively reverse disease progression in mid-to-late stages
