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In the Award 11 Study 1,842 adults with type 2 diabetes were given 1.5mg, 3mg or 4.5mg weekly doses

All DPP4i are more selective for DPP4 compared to other enzymes in the same family, such as FAP, DPP8, and DPP9, with selectivity ranging from less than 100fold for vildagliptin and saxagliptin to more than 14 000fold for alogliptin [66]

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More channels means more pathways for the medication to influence your metabolism, but it also means more complexity and, potentially, more side effects

2022 Oct 6;116(4):953969
